Mystical Frames will grant mostly a +1 increase to combat abilities the exception being Masterwork runes that instead give +3 to secondary attributes like Memory or Wits. This means aim to only place Large or Giant size runes into a frame. However, once a rune is placed in a frame it can never be removed. Superior Pixie Dust: Superior Stardust, Bonedustįrames can be added to a rune to give it even more bonuses.
As with most crafting, you may have to separate items into singles to avoid combination errors. Additionally, if you have access to the Lady Vengeance you can ask Han to fetch your items.
The supplies can be found all throughout Rivellon.
Instead, consider crafting some runes yourself. However, it can take time to gather up a collection this way. Runes can be found throughout your adventure, either as treasure or from merchants.